Orphan Black raises philosophical issues, as well as ethical and policy questions. What makes a person unique? Should we have a say in whether we're cloned? Is it immoral to generate clones with built-in defects? What does the behavior of the Clone Club tell us about the nature-nurture debate? Is it relevant that most are heterosexual, one is a lesbian, and one is a transgendered male?

Orphan Black shows us problems of biotechnology that will soon be everyday issues. What kind of a future faces us when human clones are commonplace? Will groups of clones have a tight bond of solidarity, making them a threat to democracy? If the world is going to be taken over by an evil conspiracy, would a scientific cult like Neolution or a religious cult like the Prolethians be better? Should biotech corporations be able copyright human DNA? What rules of morality apply when you can't trust the police?