The Mexican folk saint adorably known as Nuestra Señora de la Santa Muerte (Our Lady of the Holy Death) has become the object of a growing spiritual tradition and global movement. The mysteries and devotional practices that constitute the fabric of Santa Muerte's legacy run as deep as its indigenous origins. Although the worship of Santa Muerte has been condemned by the Catholic Church and other clergies, it has become an intrinsic part of Mexican culture. Today, people from all walks of life and religious paradigms have found prosperity under the cloak of Holy Death's protection and miraculous gifts of loving-kindness. Santa Muerte: The Gnostic Bible of Holy Death reveals the unknown beginnings and deeply rooted alchemical principles that are embedded in the veneration of La Santisima Muerte. The science of Holy Death has ancient roots and a profound cosmology that is an important part of understanding Santa Muerte's gnosis. This text includes an English rendering of the "Gospel of Santa Muerte" and additional esoteric and ritual practices are included.