Murder and Meth in the High Desert is the true story of the 1987 kidnapping and murder of police drug informant Denise Williams. The book follows the lives of the victim, the suspects, and the police officers who investigated the case. One suspect is murdered prior to being convicted. One suspect pleads guilty, and the other stands trial for the murder. The book follows the trial and appeals of this suspect, with actual court testimony from some of the many court trials and hearings. Alan Creech, the lead detective on the Denise Williams case, becomes obsessed with solving the murder. The book describes the many twists and turns the case takes, including the theft of evidence and the attempted murder of a police service dog.