Native American Bryson Keahbone, a marathon champion, turns his back on the running world and society after the death of his wife. He spends the next two years running from the demons of his past, feeling like he is cursed for everyone that he has ever loved meets a tragic death.

Bryson returns to his native home deep in the black hills of southeastern Oklahoma, where he butts heads with his new, beautiful, control-freak boss, Principal Piper Hitchcock, who distrusts men due to an unfaithful ex-husband. Through Bryson's friendship with Piper's son, Jared, they both lower their protective wall around their hearts and begin to fall in love.

But like everything else in Bryson's life, it would not last. Piper and Jared are kidnapped by a land-hungry demonic family, the Mongers. The only way Bryson can save them is to participate in the Mongers' murderous game, the Running Moon. As Bryson competes, he must draw on his ancestral skills along with the help of a mysterious wolf to survive the game. During the Running Moon, Bryson makes a startling discovery that will change his life forever.