Luisa Abrego, an enslaved woman in Seville, is impregnated by her master, then set free upon his death. With limited options for her future, Luisa agrees to marry a white man who wants to take her with him to Mexico, even though it means leaving her infant son behind in the care of nuns. The couple set off on a dangerous sea voyage and a perilous trek across unconquered territory, and when the settlers' caravan is attacked by Indigenous warriors, Luisa is forced to kill a man in self-defence. Years later, still wracked with guilt and convinced she must atone for her sin, Luisa confesses to having made a promise of marriage to another man long before, in Spain. By the laws of the church this makes her a bigamist, a criminal who must be tried by the fearsome Inquisition.

Based on sixteenth-century trial records of the real Luisa, this novel is not just one woman's life in fragments but a carefully researched imagining, told in the vivid, distinct voices of the Europeans who came into contact with her.