Sage Weiss loses his mother in an unimaginable murder. After he returns home to investigate, he suffers a second heartbreak when his fiancée is murdered. While recovering from the horrific losses, he stumbles onto a theory that leads him to discover that some humans have genetic predispositions to be attracted to one another. These dispositions also create the reasons that we hate one another and even explain why some people kill.

Along with his brother, Parker, and Detective Johnson, Sage uncovers evidence that indicates that these circumstances develop based on conditions surrounding one's conception. The trio must locate the origin of the phenomenon and the people responsible before they fall victim to the killers.