A mysterious pandemic causes a quarter of the world to permanently lose the ability to sleep--without any apparent health implications. The outbreak creates a new class of people who are both feared and ostracized, most of whom optimize their extra hours to earn more money.

Journalist Jamie Vega is Sleepless: he can't sleep, nor does he need to. When his boss dies on the eve of a controversial corporate takeover, Jamie doesn't buy the too-convenient explanation of suicide, and launches an investigation of his own.

But everything goes awry when Jamie discovers that he was the last person who saw Simon alive. Not only do the police suspect him, Jamie himself has no memory of that night. Alarmingly, his memory loss may have to do with how he became Sleepless: not naturally, like other Sleepless people, but through a risky and illegal biohacking process.

As Jamie delves deeper into Simon's final days, he tangles with extremist organizations and powerful corporate interests, all while confronting past traumas and unforeseen consequences of his medical experimentation. But Jamie soon faces the most dangerous decision of all as he uncovers a terrifying truth about Sleeplessness that imperils him--and all of humanity.