New York City is miles from Salt Lick, Texas, in more ways than one, but Debbie Sue Overstreet and Edwina Perkins-Martin are rarin' to go. The best friends/beauty shop owners/private-eye partners have been offered an all-expense-paid trip to the National Association of Private Investigators convention in the Big Apple. Debbie Sue sees the invitation as validation, but Edwina has one goal: to get her feet into a pair of super-glam designer shoes, not easily had back home. Yee-haw!

As a sign of things to come, the two Texas tornadoes don't even get out of the state without causing pandemonium at the Dallas airport. And once they land in the Big City they meet Celina, a small-town librarian who's broke and bereft from getting robbed, and Cher, an amiable working girl with a heart of gold. Taking them under their wings, they head right for trouble as Edwina nearly starts a riot in the hotel bar.

But the Big Apple hasn't seen nothin' yet! While helping shy Celina hook up with a hunky young police detective, the Domestic Equalizers bumble their way into a murder investigation that could end up leaving Debbie Sue deceased and Edwina stone-cold in her new Jimmy Choos!