The Case-Book of Sherlock Holmes is the final set of twelve (out of a total of fifty-six) Sherlock Holmes short stories by Arthur Conan Doyle first published in the Strand Magazine between October 1921 and April 1927.

• The Adventure of the Illustrious Client
• The Adventure of the Blanched Soldier
• The Adventure of the Mazarin Stone
• The Adventure of the Three Gables
• The Adventure of the Sussex Vampire
• The Adventure of the Three Garridebs
• The Problem of Thor Bridge
• The Adventure of the Creeping Man
• The Adventure of the Lion's Mane
• The Adventure of the Veiled Lodger
• The Adventure of Shoscombe Old Place
• The Adventure of the Retired Colourman