It is 1950 and Kitty Longthorne is now a Sister at Manchester's Park Hospital, and as busy as ever. With dizzying numbers of children with polio being admitted to the children's ward, a sharp uptick of major trauma from road accidents and growing political and racial conflict affecting her patients and staff, there's no shortage of drama at the hospital. But Kitty is determined that everyone is treated with respect.

Outside of the hospital, Kitty is finally ready to marry her fiancé, Dr James Williams. But with the growing Cold War tensions, Kitty and James come under scrutiny because of two people close to their hearts. With any suspicious activity grounds for treason, their happily ever after is suddenly on shaky ground... will they ever be able to set a date for the wedding?