Knight, a Labrador retriever, finds himself alone and afraid in the aftermath of a devastating pandemic, forced to hunt and scavenge in the city abandoned by its former masters. His fortunes change when he encounters a wounded wolf. Seeing a chance for survival and companionship, he defies the only life he has ever known and forms an uneasy alliance with his wild counterpart. Together, the two journey through a new and terrible world-a world that seems to hold no place for either dog or wolf.