Self-taught artist Rose O'Neill leaves the Midwest for New York in 1893, determined to become an illustrator in a field dominated by males. Mindful of her duty to the impoverished family she left behind, Rose's obligations require her to yield to the men who hold the reins of her career.

Yet despite the obstacles facing her, she excels at her craft, eventually designing a new character, the Kewpie. Her creation explodes into a phenomenon, but Rose's disenchantment with the status quo fosters new ambitions. She must decide whether to remain within the boundaries dictated for her, or risk everything she's gained to pursue the creative and personal passions that ignite her soul.

The Rose of Washington Square is the story of a remarkable artist, writer, suffragist, and philanthropist whose talents lifted her from obscurity into one of the most famous women of her era.