The beautiful Margaret Odell, famous Broadway beauty and ex-Follies girl known as "The Canary", is found murdered in her apartment. She has a number of men in her life, ranging from high society to gangsters, and more than one man visited her apartment on the night she dies. It is Philo Vance's characteristic erudition that leads him to a key clue that allows him to penetrate a very clever alibi and reveal the killer. "The strangeness, the daring, the seeming impenetrability of the crime marked it as one of the most singular and astonishing cases in New York's police annals; and had it not been for Philo Vance's participation in its solution, I firmly believe it would have remained one of the great unsolved mysteries of this country."

A film, The Canary Murder Case, was made by Paramount Pictures in 1929, directed by Malcolm St. Clair and Frank Tuttle and starring William Powell as Philo Vance and Louise Brooks as the Canary.