Resident Evil: The Darkside Chronicles focuses on the story of Leon Kennedy four years after the t-virus outbreak in Raccoon City . Jack Krauser , an American Special Forces operative, accompanies Kennedy into a South American village to search for Javier Hidalgo , a former drug lord with ties to the Umbrella Corporation . They quickly discover the village has suffered a viral outbreak and is overrun with zombies and mutant bio-organic weapons ( BOWs). The duo fights past the creatures and finds Javier's daughter, Manuela , who agrees to guide them through the jungle.

Manuela reveals her father treated her with the Veronica virus to cure a terminal illness. The group arrives at Javier's mansion and battle waves of Javier's experimental BOWs. They encounter Hilda , Manuela's mother, who transforms into a ravenous monster after succumbing to the Veronica virus. Kennedy dispatches Hilda, but Krauser severely injures his arm during the battle. Javier attempts to overpower Kennedy and Krauser by merging with a massive BOW called V-Complex. Manuela, in turn, uses the powers of Veronica virus to aid Kennedy and Krauser in defeating Javier. The three escape the compound with a helicopter ...