Hailing from a cycling-mad family from Cardiff, Luke Rowe represented Great Britain at junior and under-23 level. He turned professional with Team Sky in 2012 and won a stage of the Tour of Britain that season. He quickly established himself as one of the British team's key riders in both the one-day Classics and the Grand Tours, including the Tour de France.

Luke rode the Tour in every season between 2015 and 2022, playing a key role as the road captain as Sky won the yellow jersey in 2015, 2016, 2017 and 2018, and when Ineos retained the title in 2019. After retiring in 2024, Luke co-presents the Watts Occurring podcast along with his teammate and long-time friend Geraint Thomas.