Samantha Downing was born in the Bay Area, and currently lives in New Orleans. Her debut novel, My Lovely Wife, was a Richard and Judy Book Club pick and a Sunday Times bestseller, and has been published in thirty languages. It won a Dead Good Reader Award, and was shortlisted for four other major awards: The CWA John Creasey Dagger, The Edgar Award for Best First Novel, The ITW Thriller Award for Best First Novel and The Macavity Award for Best First Mystery. Amazon Studios and Nicole Kidman's Blossom Films have partnered to produce a feature film based on the novel.

Her second novel, He Started It, was also a Sunday Times bestseller and her third novel, For Your Own Good, will soon be adapted for HBO Max by Robert Downey Jr. and Greg Berlanti.